Genetic characteristics of stroke

In the recent years there is a growing interest in identification of additional genetic factors of stroke. A growing body of evidence supports the role of genetic factors in determining the risk of both hemorrhagic and ischemic stroke. The article considers the main genes associated with susceptibil...

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Bibliographic Details
Published in:	Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova Vol. 119; no. 12. Vyp. 2; p. 65
Main Authors:	Khasanova, L T, Stakhovskaya, L V, Koltsova, E A, Shamalov, N A
Format:	Journal Article
Language:	English Russian
Published:	Russia (Federation) 2019
Subjects:	Brain Ischemia - complications Brain Ischemia - genetics Genetic Predisposition to Disease Humans Polymorphism, Genetic Risk Factors Stroke - etiology Stroke - genetics polymorphism genes risk factor stroke genetic testing
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Summary:	In the recent years there is a growing interest in identification of additional genetic factors of stroke. A growing body of evidence supports the role of genetic factors in determining the risk of both hemorrhagic and ischemic stroke. The article considers the main genes associated with susceptibility to stroke and genetic polymorphisms associated with the disease. Genetic factors, modulating inflammation process, coagulation, lipid metabolism, NO formation, renin-angiotensin-aldosterone system and homeostasis play a significant role in stroke development. A comprehensive analysis of different genes associated with stroke may help to detect individuals with extremely high risk of stroke and implement timely preventive measures to decrease stroke burden.
ISSN:	1997-7298
DOI:	10.17116/jnevro201911912265