THE ROLE OF TNF-α AND IL-6 CYTOKINE IN CHILDREN WITH STATUS EPILEPTICUS

• Published in: MNJ (Malang Neurology Journal) (Online) Vol. 4; no. 2; pp. 53 - 58
• Main Authors: Wibowo, Agung Prasetyo, Sujuti, Hidayat, Rahayu, Masruroh, Muid, Masdar, Kawuryan, Siti Lintang
• Format: Journal Article
• Language: English
• Published: University of Brawijaya 01-07-2018
• Subjects: children; IL-6; status epilepticus; TNF-α
• ISSN: 2407-6724; 2442-5001
• DOI: 10.21776/ub.mnj.2018.004.02.2

Background. One of pediatric emergencies that has high mortality is status epilepticus (SE). Correlation between tumor necrosis factor (TNF)-α, interleukin (IL)-6, and SE had been reported but human study of it is limited. Objective. To compare TNF-α and IL-6 level in children with SE to those of children without SE and to find correlation between both cytokines. Methods. Cross-sectional study was conducted in dr.Saiful Anwar Hospital Malang with 48 children were enrolled in this study. All subjects were divided into three groups, including children who had SE; children who had seizure but not SE; and children who have no seizure. The levels of TNF-α and IL-6 serum were measured by ELISA. Results. TNF-α and IL-6 serum level were not significantly different between groups (p=0.920, p=0.829). We found interesting fact that the level of IL-6 in children with SE who have no disability was significantly higher than that of children who died or had disability (p=0.015). There was strong correlation between TNF-α and IL-6 in SE group (R 2 = 0.841 and p = 0.0001). Conclusion. IL-6 serum level was higher in SE children who have no disability and correlate with TNF-α serum level.