Development of alternative methodology for normalization of the small animals PET scanner of LIM/CDTN

Normalization is a step taken to correct variations in count rates between detection channels of small animals PET scanners. In general, in laboratory practice, normalization is performed using a commercial source of germanium 68. Given the half-life of the Ge-68 isotope, the normalization source mu...

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Bibliographic Details
Published in:	Brazilian Journal of Radiation Sciences Vol. 12; no. 1; p. e2360
Main Authors:	Silva, Anna Clara Moreira da, Moreira, Victória Garcia, Mendes, Bruno Melo, Gontijo, Rodrigo Modesto Gadelha, Ferreira, Andrea Vidal
Format:	Journal Article
Language:	English
Published:	Brazilian Radiation Protection Society (Sociedade Brasileira de Proteção Radiológica, SBPR) 23-02-2024
Subjects:	18F-FDG Ge-68 source Normalization Small Animal PET Scanner
Online Access:	Get full text
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Summary:	Normalization is a step taken to correct variations in count rates between detection channels of small animals PET scanners. In general, in laboratory practice, normalization is performed using a commercial source of germanium 68. Given the half-life of the Ge-68 isotope, the normalization source must be replaced every two years at most, which generates a significant spent for the Laboratory. The objective of this work was to develop and test an alternative rechargeable source to be used on normalization routine. The results indicated that the rechargeable source (18F-FDG) can be used to replace the commercial source.
ISSN:	2319-0612 2319-0612
DOI:	10.15392/2319-0612.2024.2360