18F-FES radiation dosimetry preliminary estimates for preclinical studies based on voxelized phantom

• Published in: Brazilian Journal of Radiation Sciences Vol. 10; no. 4; pp. 1 - 12
• Main Authors: Ferreira, Andréa Vidal, Bispo, Ana Carolina Araujo, Leite, Christiane Silva, Silva, Juliana Batista da, Mamede, Marcelo, Gontijo, Rodrigo Modesto Gadelha, Mendes, Bruno Melo
• Format: Journal Article
• Language: English
• Published: Brazilian Radiation Protection Society (Sociedade Brasileira de Proteção Radiológica, SBPR) 20-12-2022
• Subjects: 18F-FES; preclinical studies; radiation dosimetry
• ISSN: 2319-0612; 2319-0612
• DOI: 10.15392/2319-0612.2022.2089

Small animals, such as mice, are used in radiopharmaceutical biodistribution studies and innumerous others preclinical investigations involving ionizing radiation. Longitudinal preclinical studies with five or more image procedures, involving radiopharmaceuticals injection and/or X-radiation, are not uncommon. However, a suitable dosimetric evaluation is not always available and, sometimes, absorbed doses in animal organs or tissues and their influence in experimental results were not appropriately taken into account. Accurate calculation of absorbed doses in mice organs are needed to evaluate potential radiobiological effects that may interfere with in vivo experiments. In this work, we perform a preliminary 16α-[18F]-fluoro-17β-estradiol (18F-FES) radiation dosimetry estimates for female mice. The obtained animal dosimetric results can be useful for evaluating animal doses during the design of longitudinal preclinical studies.