Blood Lipoproteins during Surgical Myocardial Revascularization

• Published in: Obshchai͡a︡ reanimatologii͡a Vol. 4; no. 2; p. 33
• Main Authors: Shcherbakova, L. N., Chernysheva, G. G., Nikiforov, Yu. V., Molchanova, L. V.
• Format: Journal Article
• Language: English
• Published: Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia 20-04-2008
• ISSN: 1813-9779; 2411-7110
• DOI: 10.15360/1813-9779-2008-2-33

Objective: to study changes in lipid metabolic parameters during surgical myocardial revascularization and the informative value of the parameters as predictors of the postoperative course of the disease. Subjects and methods: The concentrations of triglycerides, total cholesterol (TC), and cholesterols of high-density lipoprotein (HDL), low-density lipoprotein (LDL), and very low-density lipoprotein (VLDL) were measured in 37 patients with acute coronary syndrome and chronic ischemic heart disease who had undergone surgical myocardial revascularization. Results and discussion. In all the examinees, the preopera-tive concentrations of TC and LDL cholesterol were higher than the recommended target values in cardiovascular diseases. By discharge the total concentration of proatherogenic particles significantly decreased only in acute coronary syndrome. In chronic ischemic heart disease, the total concentration of blood proatherogenic particles remained unchanged as compared with the baseline values. If postoperative complications occurred, surgery was preceded by the development of hypertriglyceridemia and hyperprebetalipoproteinemia and the proatherogenic nature of the lipoprotein profile increased by discharge due to the reduced concentration of antitherogenic HDL. Conclusion. Concomitance of postoperative complications with preoperative positive changes in the concentrations of triglycerides and VLDL allows these parameters to be used as predictors of the postoperative course of the disease. To facilitate the course of the disease, it is expedient to correct dyslipoproteinemia before and after surgical myocardial revascularization. Key words: lipoproteins, dyslipoproteinemia, atherogenic particles, myocardial revascularization, atherogenicity index.