Kaposi sarcoma among people living with HIV in the French DAT ’ AIDS cohort between 2010 and 2015

• Published in: Journal of the European Academy of Dermatology and Venereology Vol. 34; no. 5; pp. 1065 - 1073
• Main Authors: Poizot‐Martin, I., Obry‐Roguet, V., Duvivier, C., Lions, C., Huleux, T., Jacomet, C., Ferry, T., Cheret, A., Allavena, C., Bani‐Sadr, F., Palich, R., Cabié, A., Fresard, A., Pugliese, P., Delobel, P., Lamaury, I., Hustache‐Mathieu, L., Brégigeon, S., Makinson, A., Rey, D.
• Format: Journal Article
• Language: English
• Published: Wiley 01-05-2020
• Subjects: Acquired Immunodeficiency Syndrome; Herpesvirus 8, Human; HIV Infections / complications; HIV Infections / drug therapy; HIV Infections / epidemiology; Humans; Life Sciences; Retrospective Studies; Sarcoma, Kaposi / epidemiology
• ISSN: 0926-9959; 1468-3083
• DOI: 10.1111/jdv.16204

Abstract
Background
Although antiretroviral therapy (
ART
) has reduced the risk of Kaposi sarcoma (
KS
),
KS
cases still occur in
HIV
‐infected people.
Objective
To describe all
KS
cases observed between 2010 and 2015 in a country with high
ART
coverage.
Methods
Retrospective study using longitudinal data from 44 642 patients in the French Dat’
AIDS
multicenter cohort. Patients’ characteristics were described at
KS
diagnosis according to
ART
exposure and to
HIV
‐plasma viral load (
HIV
‐
pVL
) (≤50 or >50) copies/
mL
.
Results
Among the 209
KS
cases diagnosed during the study period, 33.2% occurred in
ART
naïve patients, 17.3% in
ART
‐experienced patients and 49.5% in patients on
ART
, of whom 23% for more than 6 months. Among these patients, 24 (11.5%) had
HIV
‐
pVL
≤50 cp/
mL
, and 16 (66%) were treated with a boosted‐
PI
‐based regimen. The distribution of
KS
localization did not differ by
ART
status nor by year of diagnosis.
Limitations
Data on human herpesvirus 8, treatment modalities for
KS
and response rate were not collected.
Conclusion
Half of
KS
cases observed in the study period occurred in patients not on
ART
, reflecting the persistence of late
HIV
diagnosis. Factors associated with
KS
in patients on
ART
with
HIV
‐
pVL
≤50 cp/
mL
remain to be explored.