Quasi-MOF-Engineered MnO x /CeBTC Multinanozyme as a Robust Self-Cascade ROS Generator toward Antibacterial Face Mask

• Published in: Advanced healthcare materials Vol. 13; no. 15; p. e2304141
• Main Authors: Meng, Yuqi, Han, Ruiting, Tian, Qing, Chen, Yao, Zhang, Lianbing
• Format: Journal Article
• Language: English
• Published: Germany 01-06-2024
• Subjects: Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Cerium - chemistry; Cerium - pharmacology; Escherichia coli - drug effects; Manganese Compounds - chemistry; Manganese Compounds - pharmacology; Masks; Metal-Organic Frameworks - chemistry; Metal-Organic Frameworks - pharmacology; Oxides - chemistry; Reactive Oxygen Species - metabolism; multinanozyme; cascade reaction; nanobactericide; reactive oxygen species; quasi‐metal organic framework
• ISSN: 2192-2640; 2192-2659
• DOI: 10.1002/adhm.202304141

It is of great importance to endow personal protective equipments with bactericidal property combating against infected pathogens. Nanozyme that can generate reactive oxygen species (ROS) in an enzyme-catalytic manner is regarded as a novel and promising nanobactericide. But until now, very rare of them is designed specifically for personal protective equipments. In this study, a multinanozyme of manganese oxide supported on Ce-containing MOF (CeBTC) is constructed with post-engineering via a quasi-metal-organic framework (MOF) strategy (denoted as MnO
/q-CeBTC). The strategy enables a full exposure of the metal cluster nodes, introduction of new active Mn─O─Ce bonds and strengthens interaction between the metal nodes and the guest oxide. As an advanced multinanozyme, the MnO
/q-CeBTC exhibits excellent multiple enzymatic activities at low temperature, and enables abundant and self-cascade ROS generation without H
O
addition. This empowers it with high efficiency in bacteria killing, which is also reflected when incorporated into face mask to combat against pathogen invasion even at low temperature. The results achieved in this work provide guidance for rational design of effective bactericide based on nanozyme and broaden their application in personal protective equipment and other fields.