EFFECT OF FENBENZYL AND FENBENDAZOLE ON THE ANTIOXIDANT STATUS IN DOGS DURING EXPERIMENTAL INFECTION WITH CAUSATIVE AGENT OF TOXOCARIASIS

• Published in: Ukrainian Journal of Veterinary Sciences Vol. 12; no. 2; pp. 5 - 14
• Main Authors: V. V., Stybel, B. V., Gutyj, W. S., Said, K., KUBIAK, M., Jankowski, I. A., Maksymovych, Z. A., Guta, T. V., Martyshuk, V. I., Karpovskyi
• Format: Journal Article
• Language: English
• Published: National University of Life and Environmental Sciences of Ukraine 30-06-2021
• Subjects: broiler chickens; doxycycline hyclate; ornithobacteriosis; ornithobacterium rhinotracheale; pharmacokinetic parameters; pollodoxin
• ISSN: 2663-967X; 2663-9688
• DOI: 10.31548/ujvs2021.02.001

The article presents the results of studies of the effect of fenbenzyl and fenbendazole on the antioxidant status in dogs under the experimental infection with a causative agent of toxocariasis. Experiments were performed on 18 dogs, two and four months old. Three groups of six animals in each were formed: control and two experimental. Puppies in all groups were experimentally infected with causative agent of toxocariasis at a dose of 5.000 embryonated Toxocara canis eggs per kg of body weight. The control group of dogs was as untreated control. Puppies of the first experimental group were fed with the drug fenbendazole at a dose of 150 mg per 3 kg of body weight once a day for three days in a single dose. Puppies of the second experimental group were fed with the drug fenbenzyl at a dose of 350 mg per 3 kg of body weight once a day for three days. While studying the activity of the enzymatic part of the antioxidant defense system, namely catalase, superoxide dismutase, glutathione peroxidase, glutathione reductase, as well as a non-enzymatic part: the level of reduced glutathione, an increase in the activity of these indicators was found in animals of experimental groups. It should be noted that the application of the drug fenbenzyl in infected dogs contributed to a better normalization of the antioxidant system in animals than the use of the drug fenbendazole. The use of fenbenzyl in infected dogs contributed to a more likely increase in the antioxidant status in dogs of the second experimental group, as this drug includes milk thistle that exhibits antioxidant properties due to the presence of silymarin, which restores damaged liver cells. Studies confirm the effectiveness of the use of milk thistle in drug fenbenzyl in dogs with the development of toxocariasis infection to activate the protective systems of their body