Leiomyosarcoma and ulcerative colitis: Case report

• Published in: Revista Colombiana de Gastroenterología Vol. 35; no. 1; pp. 123 - 126
• Main Authors: Delgado Martínez, Carolina, San Miguel Amelivia, Elena, Savescu, Theodora, Butrón Villa, Mercedes
• Format: Journal Article
• Language: English
• Published: Asociación Colombiana de Gastroenterología 27-03-2020
• Subjects: dysplasia screening; inflamatory bowel disease; leiomyosarcoma; ulcerative colitis
• ISSN: 0120-9957; 2500-7440
• DOI: 10.22516/25007440.317

Ulcerative colitis (UC) and Crohn’s disease (CD) patients present an increased risk of colorectal cancer (CRC) due to chronic inflammation, genetic susceptibility and environmental risk factors. In contrast, non-epithelial neoplasms are uncommon.
We discuss the case of an 83-year-old male with a long-standing UC, presenting with a polypoid lesion. Once resected, the lesion was identified as a high-grade leiomyosarcoma. A review of the literature revealed that only three previous cases of leiomyosarcoma among patients with UC have been published. Thus, this one would represent the fourth case where this rare non-epithelial neoplasm was detected in a patient with UC. The direct association of UC and leiomyosarcoma has not been well established; however, immunosuppression is suggested to be a risk factor for leiomyosarcoma in the literature.