Solvothermal synthesis of Zr-metal-organic framework/V2C MXene based composite on nickel foam for highly selective detection of epinephrine in simulated blood serum

• Published in: Microchemical journal Vol. 207; p. 112120
• Main Authors: Ravipati, Manaswini, Sai Deepak, Mavuri, Badhulika, Sushmee
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01-12-2024
• Subjects: Electrochemical sensor; Epinephrine; Solvothermal synthesis; V2C MXene; Zr-Metal-organic framework; Epinephrine; V2C MXene; Electrochemical sensor; Zr-Metal-organic framework; Solvothermal synthesis
• ISSN: 0026-265X
• DOI: 10.1016/j.microc.2024.112120

[Display omitted]
•Successfully fabricated a Zr-MOF/V2C MXene composite on nickel foam for efficient epinephrine detection.•The composite’s cubic structure and unique morphology of rectangular sheets boost sensitivity in epinephrine detection.•The proposed Sensor exhibits excellent selectivity towards epinephrine in the presence of common interfering species.•Zr-MOF/V2C MXene Sensor reveals dynamic linear concentration range and lower limit of detection.
Metal-organic frameworks (MOFs) combined with MXene materials have recently gained considerable attention for their unique properties, including exceptional structural characteristics and electrical conductivity. These attributes enable them to maintain a high concentration of electroactive sites, making them particularly suitable for electrochemical applications. Here, we demonstrate solvothermal synthesis of Zr-metal–organic framework (Zr-MOF)/V2C MXene composite decorated nickel foam (NF) for electrochemical detection of Epinephrine (EP) in simulated blood serum samples. X-ray diffraction analysis confirms the formation of the cubic structured Zr-MOF/V2C MXene composite. Scanning Electron Microscopy (SEM) and Transmission Electron Microscopy (TEM) reveal the existence of numerous rectangular sheets and nanospheres of the composite. Utilizing the differential pulse voltammetry (DPV) technique, the sensor demonstrates a remarkable sensitivity of 19 µA/µM.cm−2 to EP within a wide linear detection range from 1 µM to 1 mM with a lower limit of detection of 0.86 µM (=3 S/m). The fabricated sensor exhibits high selectivity against interfering species like uric acid (UA), ascorbic acid (AA), glucose (GLU), urea, etc. Real-sample analysis conducted in simulated blood samples using the standard addition method showcases an outstanding recovery percentage of approximately 100 %. Zr-MOF/V2C MXene composite, with its conductive nature and high surface area, forms a robust interaction with EP, leading to a significant alteration in the sensor’s electrical properties. Meanwhile, the porous NF substrate is crucial in maintaining stability, boosting catalytic activity by offering numerous active sites, and enabling swift electron transfer. Affirming the efficacy of the Zr-MOF/V2C MXene composite, herein, as an exceptional electrode with high performance. The composite shows significant promise in detecting various biomolecules essential for biomedical research applications.