Bacillus subtilis as potential producer for polyhydroxyalkanoates

• Published in: Microbial cell factories Vol. 8; no. 1; p. 38
• Main Authors: Singh, Mamtesh, Patel, Sanjay Ks, Kalia, Vipin C
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 20-07-2009; BioMed Central; BMC
• Subjects: Biomedical engineering; Poisoning; Polyhydroxybutyrate; Polymers; Review; Soil inoculation
• ISSN: 1475-2859; 1475-2859
• DOI: 10.1186/1475-2859-8-38

Polyhydroxyalkanoates (PHAs) are biodegradable polymers produced by microbes to overcome environmental stress. Commercial production of PHAs is limited by the high cost of production compared to conventional plastics. Another hindrance is the brittle nature and low strength of polyhydroxybutyrate (PHB), the most widely studied PHA. The needs are to produce PHAs, which have better elastomeric properties suitable for biomedical applications, preferably from inexpensive renewable sources to reduce cost. Certain unique properties of Bacillus subtilis such as lack of the toxic lipo-polysaccharides, expression of self-lysing genes on completion of PHA biosynthetic process - for easy and timely recovery, usage of biowastes as feed enable it to compete as potential candidate for commercial production of PHA.