The neurobiology of stress and gastrointestinal disease

• Published in: Gut Vol. 47; no. 6; pp. 861 - 869
• Main Author: MAYER, E A
• Format: Journal Article Book Review
• Language: English
• Published: London BMJ Publishing Group Ltd and British Society of Gastroenterology 01-12-2000; BMJ; BMJ Publishing Group LTD
• Subjects: Adaptation, Physiological; Adaptation, Psychological; Autonomic Nervous System Diseases - complications; Autonomic Nervous System Diseases - physiopathology; Biological and medical sciences; Chronic fatigue syndrome; Gastroenterology. Liver. Pancreas. Abdomen; Gastrointestinal Diseases - physiopathology; Gastrointestinal Diseases - psychology; Homeostasis; Homeostasis - physiology; Humans; Inflammatory bowel disease; Irritable bowel syndrome; Medical sciences; Neurobiology; Neurosciences; Other diseases. Semiology; Pain; Patients; Physiology; Review; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Stress; Stress response; Stress, Mechanical; Stress, Psychological - complications; Stress, Psychological - physiopathology; Ulcers; Human; Gastroesophageal reflux; Pathogenesis; Psychology; Esophageal disease; Gut; Gastrointestinal; Inflammatory disease; Restraint stress; Dysfunction; Digestive diseases; Intestinal disease; Mechanism of action; Gastric disease
• ISSN: 0017-5749; 1468-3288; 1458-3288
• DOI: 10.1136/gut.47.6.861

[...]recent evidence suggests a role for endogenous pain modulation systems in stress induced increase in oesophageal chemosensitivity. 168 In conclusion, recent breakthroughs in understanding the neurobiology of stress emphasise the importance of the peripheral outputs of the central stress response in the modulation of some of the most common gastrointestinal disorders.