Effects of balloon occlusion during percutaneous coronary intervention on circulating Ischemia Modified Albumin and transmyocardial lactate extraction

• Published in: Heart (British Cardiac Society) Vol. 92; no. 12; pp. 1852 - 1853
• Main Authors: Sinha, M K, Vazquez, J M, Calvino, R, Gaze, D C, Collinson, P O, Kaski, J C
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group Ltd and British Cardiovascular Society 01-12-2006; BMJ; BMJ Publishing Group LTD; BMJ Group
• Subjects: Acute coronary syndromes; Angioplasty, Balloon, Coronary; Balloon Occlusion; Biological and medical sciences; Cardiology. Vascular system; Cobalt; Confidence intervals; Coronary heart disease; Coronary vessels; Diseases of the cardiovascular system; Heart; Humans; IMA; Ischemia; Ischemia Modified Albumin; Lactic Acid - metabolism; Medical sciences; Metabolism; Myocardial Ischemia - metabolism; Myocardial Ischemia - therapy; PCI; percutaneous coronary intervention; Plasma; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects); Scientific Letter; Serum Albumin - metabolism; Studies; Veins & arteries; Occlusion; Angioplasty; Coronary artery; Albumin; Instrumentation therapy; Cardiovascular disease; Coronary heart disease; Phlebology; Stent; Lactates; Ischemia; Extraction; Circulatory system; Lactic acid; Cardiology
• ISSN: 1355-6037; 1468-201X
• DOI: 10.1136/hrt.2005.078089

METHODS We simultaneously measured coronary sinus and arterial lactate concentrations and plasma IMA levels before and after balloon inflation in 10 patients with chronic stable angina undergoing PCI to the proximal left anterior descending coronary artery. With re-oxygenation of ischaemic tissue there is a rapid release of reactive oxygen species, followed by the release of lipids, protein peroxidation products and lactate into the circulation that peaks in the first 1-5 min of reperfusion, and declines after 2-5 min. 5 This is the first study to compare transmyocardial lactate production and plasma IMA changes in the context of cardiac ischaemia induced by balloon inflation.