Intestinal permeability in Behçet's syndrome

• Published in: Annals of the rheumatic diseases Vol. 60; no. 1; pp. 65 - 66
• Main Authors: Fresko, I, Hamuryudan, V, Demir, M, Hızlı, N, Sayman, H, Melikoğlu, M, Tunç, R, Yurdakul, S, Yazıcı, H
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group Ltd and European League Against Rheumatism 01-01-2001; BMJ; BMJ Publishing Group Ltd; BMJ Publishing Group LTD
• Subjects: 51Cr-EDTA; Adult; Behcet Syndrome - physiopathology; Behcet's disease; Behçet's disease; Biological and medical sciences; Chromium Radioisotopes; Concise Report; Edetic Acid; Female; Hospitals; Humans; Inflammation; Inflammatory bowel disease; Inflammatory Bowel Diseases - physiopathology; Intestinal Absorption; Intestines; Lupus; Lupus Erythematosus, Systemic - physiopathology; Male; Medical sciences; Molecular weight; Permeability; Physiological aspects; Radioactivity; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Spondylitis, Ankylosing - physiopathology; Urine; Variance analysis; Turkey; Radionuclide study; Human; Skin disease; Stomatology; Gut; Cardiovascular disease; Inflammation; Radioactive tracers; Behçet syndrome; Genital diseases; Vascular disease; Eye disease; Systemic disease; Permeability barrier
• ISSN: 0003-4967; 1468-2060
• DOI: 10.1136/ard.60.1.65

OBJECTIVE To measure the intestinal permeability in patients with Behçet's syndrome (BS) and to compare the results with those obtained from healthy and diseased controls. METHOD The study group comprised 34 patients with BS without known gastrointestinal disease. Ten patients with ankylosing spondylitis (AS), 6 with inflammatory bowel diseases (IBD), 17 with systemic lupus erythematosus (SLE), and 15 healthy subjects (HC) constituted the controls. All patients received 100 μCi (3.7 MBq) of chromium-51 EDTA (51Cr-EDTA) as a radioactive tracer after a 72 hour abstinence from all drugs. The percentage of the isotope excreted in a 24 hour urinary specimen was the measure of permeability. RESULTS The percentage (SD) rate of excretion of 51Cr-EDTA was 4.6 (2.6) in BS, 6 (2.4) in AS, 5.2 (1.9) in IBD, 5.56 (1.78) in SLE, and 2.3 (1) in healthy controls. (Analysis of variance: f=6.4, p=0.0002. BSv HC, AS vHC, SLE v HC significant.) CONCLUSION The intestinal permeability in BS was significantly more than that seen among the healthy controls. Similar results in all the diseased controls cast doubt on its specificity.