Effects of exposure to quantum dots in the external and internal environments of organisms

• Main Author: Leigh, Kenton L
• Format: Dissertation
• Language: English
• Published: Ann Arbor ProQuest Dissertations & Theses 2016
• Subjects: Environmental science; Molecular biology; Nanotechnology
• ISBN: 9781369416251; 1369416253

The use of nanotechnology in research and consumer products is increasing, but there are few studies regarding the safety of nanoparticles (NPs). NPs’ small size and increased surface area allow for unique physical and chemical properties not seen in bulk counterparts of the same material. Thus, NP interactions within environmental and biological matrices are not well understood. Specifically, quantum dots (QDs) have garnered increased attention due to their superior optical properties. However, little research on the effects of QDs on the environment is available. The studies described herein provide data regarding interactions of QDs in aquatic and terrestrial environments using methods that mimicked realistic exposures. First, fish were exposed to QD-contaminated water to study time- and dose-dependent QD uptake. Secondly, mice were exposed to a QD-containing aerosol to determine whether QD exposure could influence pulmonary cytokine production. These studies provide useful information on the interactions of QDs with the environment.