An evaluation of the antidiabetic effects of Elaeocarpus ganitrus in experimental animals

• Published in: Indian journal of pharmacology Vol. 43; no. 1; pp. 56 - 59
• Main Authors: Hule, Amolkumar K, Shah, Abhishek S, Gambhire, Manoj N, Juvekar, Archana R
• Format: Journal Article
• Language: English
• Published: India Medknow Publications on behalf of Indian Pharmacological Society 01-01-2011; Medknow Publications and Media Pvt. Ltd; Medknow Publications & Media Pvt. Ltd; Medknow Publications
• Subjects: Animals; Antihyperglycemic, diabetes, Elaeocarpus ganitrus, streptozotocin; Cholesterol; Diabetes; Health aspects; Hyperglycemia; Hypoglycemic agents; Materia medica, Vegetable; Medicine, Botanic; Medicine, Herbal; Plant extracts; Properties; Rodents; Statistical analysis; Studies; Testing laboratories; Triglycerides; India; Elaeocarpus ganitrus; streptozotocin; diabetes; Antihyperglycemic
• ISSN: 0253-7613; 1998-3751
• DOI: 10.4103/0253-7613.75671

Objective : To evaluate the antidiabetic effects of the aqueous extract
of Elaeocarpus ganitrus (EAG) in experimental animals. Materials and
Methods : The hypoglycemic activity of the EGA was evaluated in
normoglycemic rats by single dose at three graded dose levels, viz.
250, 500 and 1000 mg/kg of body weight. Antihyperglycemic activity of
the extract was also evaluated at the same dose levels in
streptozotocin (STZ) (60 mg/kg, i.p.)-induced diabetic rats during a
30-day treatment period. Metformin (500 mg/kg) was used as the
reference drug. Fasting blood glucose and lipid parameters, viz.
triglycerides, total cholesterol, high-density lipoprotein and
low-density lipoprotein levels were measured. Acute oral toxicity of
the EGA extract was carried out in Swiss albino mice. Results : In
normoglycemic rats, EGA showed a significant (P < 0.01) hypoglycemic
effect at 2 h. In STZ-induced diabetic rats, the EGA treatment
significantly (P < 0.05) decreased the blood glucose level in a
dose-dependent manner during the 30 days of treatment period. EGA
modulated lipid profile changes in STZ-diabetic rats in a
dose-dependant manner. In the acute oral toxicity study, EGA showed no
mortality till the 5 g/kg dose in mice. Conclusion : The present
investigation shows that EAG seeds has potential antidiabetic effects.