Lantana montevidensis Briq improves the aminoglycoside activity against multiresistant Escherichia coli and Staphylococcus aureus

• Published in: Indian journal of pharmacology Vol. 43; no. 2; pp. 180 - 182
• Main Authors: Sousa, Erlanio O, Almeida, Thiago S, Rodrigues, Fabíola F.G, Campos, Adriana R, Lima, Sidney G, Costa, José G.M
• Format: Journal Article
• Language: English
• Published: India Medknow Publications on behalf of Indian Pharmacological Society 01-03-2011; Medknow Publications and Media Pvt. Ltd; Medknow Publications & Media Pvt. Ltd; Medknow Publications
• Subjects: Aminoglycosides; Aminoglycosides, antibacterial and modulatory activities, Lantana montevidensis Briq; Antibacterial agents; Care and treatment; Control; Escherichia coli; Escherichia coli infections; Health aspects; Materia medica, Vegetable; Medicine, Botanic; Medicine, Herbal; Plant extracts; Properties; Staphylococcus aureus; Staphylococcus aureus infections; Verbena; India; Lantana montevidensis Briq; antibacterial and modulatory activities; Aminoglycosides
• ISSN: 0253-7613; 1998-3751
• DOI: 10.4103/0253-7613.77359

Objective : In this work, we report the antibacterial and modulatory
activity of Lantana montevidensis Briq. Materials and Methods : The
antibacterial activities of leaf (LELm) and root (RELm) extracts alone
or in association with aminoglycosides were determined by a
microdilution test. Multiresistant strains of Escherichia coli (Ec
27) and Staphylococcus aureus (Sa 358) were used. Results : The
results show the inhibitory activity of LELm against E. coli (minimal
inhibitory concentration [MIC] 16 μg/mL) and S. aureus (MIC 128
μg/mL). The synergistic effect of the extracts and aminoglycosides
was verified too. The maximum effects were obtained with RELm with
gentamicin against E. coli with MIC reduction (312 to 2 μL).
Conclusion : The data from this study are indicative of the activity
antibacterial of extracts of L. montevidensis and its potential in
modifying the resistance of aminoglycosides.