Will Global Transcriptome Analysis Allow the Detection of Novel Prognostic Markers in Coronary Artery Disease and Heart Failure?

• Published in: Current genomics Vol. 14; no. 6; pp. 388 - 396
• Main Authors: Gora, Monika, Kiliszek, Marek, Burzynska, Beata
• Format: Journal Article
• Language: English
• Published: United Arab Emirates Bentham Science Publishers Ltd 01-09-2013; Bentham Science Publishers
• Subjects: Cardiovascular diseases; Heart failure; Myocardial infarction; Biomarkers; Gene expression profiling; Microarrays; Coronary artery disease
• ISSN: 1389-2029; 1875-5488
• DOI: 10.2174/1389202911314090006

Coronary artery disease (CAD) is one of the leading causes of death in the developed countries. Myocardial infarction
(MI) is an acute episode of CAD that results in myocardial injury and subsequent heart failure (HF). In the acute
phase of MI several risk factors for future cardiovascular events have been found. The molecular mechanisms of these
disorders are still unknown, but altered gene expression may play an important role in the development and progression of
cardiovascular diseases. High-throughput techniques should greatly facilitate the elucidation of the mechanisms and provide
novel insights into the pathophysiology of cardiovascular diseases. In this review we focus on the perspectives of
gene-expression profiling conducted on cardiac tissues and blood for the determination of novel diagnostic and prognostic
markers and therapeutic targets.