Role of miR-10b in breast cancer metastasis

Ninety percent of cancer-related mortality is caused by metastasis. Current cancer treatments can control many primary tumors but rarely stop the metastatic spread. Accumulating evidence demonstrates that miRNAs are involved in cancer initiation and progression. Furthermore, several miRNAs have been...

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Bibliographic Details
Published in:	Breast cancer research : BCR Vol. 12; no. 5; p. 210
Main Author:	Ma, Li
Format:	Journal Article
Language:	English
Published:	England BioMed Central Ltd 01-01-2010 BioMed Central
Subjects:	Analysis Animals Breast cancer Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - mortality Breast Neoplasms - pathology Cancer metastasis Cancer treatment Cell Line, Tumor Development and progression Female Gene Expression Regulation, Neoplastic Health aspects Humans Mice MicroRNA MicroRNAs - metabolism Mortality Neoplasm Metastasis Review
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Summary:	Ninety percent of cancer-related mortality is caused by metastasis. Current cancer treatments can control many primary tumors but rarely stop the metastatic spread. Accumulating evidence demonstrates that miRNAs are involved in cancer initiation and progression. Furthermore, several miRNAs have been found to regulate metastasis. In particular, recent studies provide the first functional evidence that overexpression of a specific miRNA, miR-10b, can contribute to the development of metastasis, which can be exploited therapeutically in treating breast cancer metastasis in mice. Further in-depth analysis should provide more precise evaluation of the roles, mechanisms, and therapeutic utility of this miRNA in breast cancer.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	1465-542X 1465-5411 1465-542X
DOI:	10.1186/bcr2720