Clinical correlates of low-risk variants in FGFR2, TNRC9, MAP3K1, LSP1 and 8q24 in a Dutch cohort of incident breast cancer cases

• Published in: Breast cancer research : BCR Vol. 9; no. 6; p. R78
• Main Authors: Huijts, Petra E A, Vreeswijk, Maaike P G, Kroeze-Jansema, Karin H G, Jacobi, Catharina E, Seynaeve, Caroline, Krol-Warmerdam, Elly M M, Wijers-Koster, Pauline M, Blom, Jannet C, Pooley, Karen A, Klijn, Jan G M, Tollenaar, Rob A E M, Devilee, Peter, van Asperen, Christi J
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 01-01-2007; National Library of Medicine - MEDLINE Abstracts; BioMed Central
• Subjects: Adult; Aged; Breast cancer; Breast Neoplasms - epidemiology; Breast Neoplasms - genetics; Cancer; Chromosomes, Human, Pair 8; Cohort Studies; Estrogen; Female; Genetic aspects; Genetic Predisposition to Disease; Genetic variation; Health aspects; Humans; Incidence; Lymphatic Metastasis; MAP Kinase Kinase Kinase 1 - genetics; Microfilament Proteins - genetics; Middle Aged; Netherlands - epidemiology; Oncology, Experimental; Ovarian cancer; Polymorphism, Single Nucleotide; Progesterone; Receptor, Fibroblast Growth Factor, Type 2 - genetics; Receptors, Progesterone - genetics; Risk factors; Single nucleotide polymorphisms; Netherlands; United Kingdom
• ISSN: 1465-542X; 1465-5411; 1465-542X
• DOI: 10.1186/bcr1793

Seven SNPs in five genomic loci were recently found to confer a mildly increased risk of breast cancer.
We have investigated the correlations between disease characteristics and the patient genotypes of these SNPs in an unselected prospective cohort of 1,267 consecutive patients with primary breast cancer.
Heterozygote carriers and minor allele homozygote carriers for SNP rs889312 in the MAP3K1 gene were less likely to be lymph node positive at breast cancer diagnosis (P = 0.044) relative to major allele homozygote carriers. Heterozygote carriers and minor allele homozygote carriers for SNP rs3803662 near the TNCR9 gene were more likely to be diagnosed before the age of 60 years (P = 0.025) relative to major allele homozygote carriers. We also noted a correlation between the number of minor alleles of rs2981582 in FGFR2 and the average number of first-degree and second-degree relatives with breast cancer and/or ovarian cancer (P = 0.05). All other disease characteristics, including tumour size and grade, and oestrogen or progesterone receptor status, were not significantly associated with any of these variants.
Some recently discovered genomic variants associated with a mildly increased risk of breast cancer are also associated with breast cancer characteristics or family history of breast cancer and ovarian cancer. These findings provide interesting new clues for further research on these low-risk susceptibility alleles.