CCR2 and CCR5 genes polymorphisms in women with cervical lesions from Pernambuco, Northeast Region of Brazil: a case-control study

• Published in: Memórias do Instituto Oswaldo Cruz Vol. 111; no. 3; pp. 174 - 180
• Main Authors: Santos, Erinaldo Ubirajara Damasceno dos, Lima, Géssica Dayane Cordeiro de, Oliveira, Micheline de Lucena, Heráclio, Sandra de Andrade, Silva, Hildson Dornelas Angelo da, Crovella, Sergio, Maia, Maria de Mascena Diniz, Souza, Paulo Roberto Eleutério de
• Format: Journal Article
• Language: English
• Published: Brazil Fundação Oswaldo Cruz, Fiocruz 01-03-2016; Instituto Oswaldo Cruz, Ministério da Saúde; Fundação Oswaldo Cruz (FIOCRUZ)
• Subjects: Adolescent; Adult; Aged; Brazil - epidemiology; Case-Control Studies; cervical cancer; cervical intraepithelial neoplasia; Cervical Intraepithelial Neoplasia - genetics; Cervical Intraepithelial Neoplasia - virology; chemokine receptors; Female; Genetic Predisposition to Disease - epidemiology; Genotype; Humans; Middle Aged; Papillomaviridae - pathogenicity; Papillomavirus Infections - epidemiology; PARASITOLOGY; Polymorphism, Genetic; Prevalence; Receptors, CCR2 - genetics; Receptors, CCR5 - genetics; single nucleotide polymorphism; Squamous Intraepithelial Lesions of the Cervix - genetics; Squamous Intraepithelial Lesions of the Cervix - virology; TROPICAL MEDICINE; Uterine Cervical Diseases - genetics; Uterine Cervical Diseases - virology; Young Adult; Brazil; chemokine receptors; single nucleotide polymorphism; cervical cancer; cervical intraepithelial neoplasia
• ISSN: 1678-8060; 0074-0276; 1678-8060
• DOI: 10.1590/0074-02760150367

Polymorphisms in chemokine receptors play an important role in the
progression of cervical intraepithelial neoplasia (CIN) to cervical
cancer (CC). Our study examined the association of CCR2-64I (rs1799864)
and CCR5-Δ32 (rs333) polymorphisms with susceptibility to develop
cervical lesion (CIN and CC) in a Brazilian population. The genotyping
of 139 women with cervical lesions and 151 women without cervical
lesions for the CCR2-64I and CCR5-Δ32 polymorphisms were performed
using polymerase chain reaction-restriction fragment length
polymorphism. The individuals carrying heterozygous or homozygous
genotypes (GA+AA) for CCR2-64I polymorphisms seem to be at lower risk
for cervical lesion [odds ratio (OR) = 0.37, p = 0.0008)]. The same was
observed for the A allele (OR = 0.39, p = 0.0002), while no association
was detected (p > 0.05) with CCR5-Δ32 polymorphism. Regarding
the human papillomavirus (HPV) type, patients carrying the CCR2-64I
polymorphism were protected against infection by HPV type 16 (OR =
0.35, p = 0.0184). In summary, our study showed a protective effect of
CCR2-64I rs1799864 polymorphism against the development of cervical
lesions (CIN and CC) and in the susceptibility of HPV 16 infection.