Nephrogenic Fibrosing Dermopathy

• Published in: Indian journal of dermatology, venereology, and leprology Vol. 75; no. 1; pp. 63 - 67
• Main Authors: Ragunatha, S, Palit, Aparna, Inamadar, ArunC, Madraki, Ravindra M, Yelikar, B.R
• Format: Journal Article
• Language: English
• Published: New Delhi Medknow Publications on behalf of The Indian Association of Dermatologists, Venereologists and Leprologists (IADVL) 01-01-2009; Indian Association of Dermatologists, Venereologists and Leprologists; Medknow Publications and Media Pvt. Ltd; Scientific Scholar
• Subjects: Adult; Biological and medical sciences; Care and treatment; Case studies; Chemicals; Dermatology; Diagnosis; Drugs; Female; Health aspects; Hemodialysis; Hepatitis; Humans; Kidney failure; Kidney Failure, Chronic - complications; Kidney Failure, Chronic - diagnosis; Kidney Failure, Chronic - drug therapy; Medical sciences; Nephrogenic Fibrosing Dermopathy - complications; Nephrogenic Fibrosing Dermopathy - diagnosis; Nephrogenic Fibrosing Dermopathy - drug therapy; Nephrogenic fibrosing dermopathy, Nephrogenic systemic fibrosis, Dialysis, Renal failure; Nephrology. Urinary tract diseases; Nephropathies. Renovascular diseases. Renal failure; Patients; Prednisolone - therapeutic use; Renal failure; Risk factors; Skin diseases; India; Kidney disease; Skin disease; Urinary system disease; Nephrogenic systemic fibrosis; Nephrogenic fibrosing dermopathy; Dermatology; Renal failure; Tropical medicine; Dialysis
• ISSN: 0378-6323; 0973-3922; 1998-3611
• DOI: 10.4103/0378-6323.45224

An adult female patient on hemodialysis for chronic renal failure
presented with large, brownish, and indurated plaques with bound-down
skin on both lower limbs and abdomen along with difficulty in movement
of the legs. Histopathological features revealed thick collagen bundles
admixed with mucin and intercalating spindle-like cells characteristic
of nephrogenic fibrosing dermopathy (NFD). Immunohistochemical study
showed prominent CD68 positivity and weak CD34 positivity suggesting
that the plaques were more than 20-weeks old. NFD in patients with
chronic renal failure of unknown cause is a poor prognostic indicator.
Early detection before the development of contracture and prompt
treatment of NFD and underlying renal failure may reverse this
disabling condition.