Hepatitis B virus infection in multitransfused haemophiliacs

• Published in: Archives of disease in childhood Vol. 61; no. 6; pp. 580 - 584
• Main Authors: Nebbia, G, Moroni, G A, Simoni, L, Belli, M, Carnelli, V
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health 01-06-1986; BMJ; BMJ Publishing Group LTD
• Subjects: Age Factors; Biological and medical sciences; Child; Child, Preschool; Chronic Disease; Factor IX - therapeutic use; Factor VIII - therapeutic use; Hematologic and hematopoietic diseases; Hemophilia A - drug therapy; Hepatitis; Hepatitis B; Hepatitis B - etiology; Hepatitis B Surface Antigens - analysis; hepatitis B virus; Humans; Infant; Italy; Longitudinal Studies; Medical sciences; Pathogens; Platelet diseases and coagulopathies; Italy; Human; Infection; Viral hepatitis B; Transfusion; Viral disease; Hemophilia; Digestive diseases; Hemopathy; Concentrate; Child; Coagulation factor; Coagulopathy
• ISSN: 0003-9888; 1468-2044
• DOI: 10.1136/adc.61.6.580

A longitudinal study of 44 haemophilic children, all in a treatment programme with factor concentrates, was undertaken to evaluate the occurrence, characteristics, and evolution of hepatitis B virus (HBV) infection. Twenty four children (55%) (group I) showed signs of HBV infection, while 20 (45%) (group II) did not. Age at onset of treatment, number of infusions, and total amount of concentrate received did not show significant differences between the two groups. In group I only four children (16%) had symptomatic acute hepatitis. Chronic liver disease was present in nine patients (38% of infected children). The early age of infection would seem to be an important factor for predicting chronic evolution. Evidence of delta infection in three children with severe liver disease seemed to confirm the high pathogenicity of this agent. Because of the risks associated with chronic HBV infection a careful follow up of patients positive for hepatitis B surface antigen is mandatory.