Combined analysis of the ORCHID and OCAY studies: does eradication of Helicobacter pylori lead to sustained improvement in functional dyspepsia symptoms?

• Published in: Gut Vol. 50; no. suppl 4; pp. iv26 - iv30
• Main Authors: Veldhuyzen van Zanten, S J O, Talley, N J, Blum, A L, Bolling-Sternevald, E, Sundin, M, Junghard, O
• Format: Journal Article Conference Proceeding
• Language: English
• Published: London BMJ Publishing Group Ltd and British Society of Gastroenterology 01-05-2002; BMJ; BMJ Publishing Group LTD
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; amoxycillin 1000 mg twice daily; and clarithromycin 500 mg twice daily for seven days; Anti-Bacterial Agents; Anti-Ulcer Agents - therapeutic use; Antibiotics; Biological and medical sciences; clinical trial; Clinical trials; Double-Blind Method; Drug Therapy, Combination - therapeutic use; dyspepsia; Dyspepsia - drug therapy; Dyspepsia - microbiology; Dyspepsia Management; Endoscopy; gastro-oesophageal reflux disease; Gastroenterology. Liver. Pancreas. Abdomen; Gastroesophageal reflux; gastrointestinal symptom rating scale; GDSS; Glasgow dyspepsia severity score; GORD; GSRS; Helicobacter Infections - complications; Helicobacter Infections - drug therapy; Helicobacter pylori; Humans; intention to treat; ITT; Likert scale; Medical Research Council; Medical sciences; Middle Aged; MRC; Multicenter Studies as Topic; OAC; OCAY study; Omeprazole - therapeutic use; omeprazole 20 mg twice daily; ORCHID study; Other diseases. Semiology; Pain; Patients; PGWB; psychological general well being; Quality of life; Questionnaires; Randomized Controlled Trials as Topic; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; symptom relief; Ulcers; Human; Spirillales; Dyspepsia; Spirillaceae; Eradication; Gastritis; Quality of life; Infection; Helicobacter pylori; Dysfunction; Bacteriosis; Digestive diseases; Bacteria; Evolution; Biological effect; Gastric disease
• ISSN: 0017-5749; 1468-3288; 1458-3288
• DOI: 10.1136/gut.50.suppl_4.iv26

Currently, one of the most important unresolved questions concerning Helicobacter pylori is whether eradication of the organism leads to a sustained improvement in symptoms in patients diagnosed with functional (non-ulcer) dyspepsia. Recently, two very similar studies, the ORCHID and OCAY studies, have been completed and the combined results of these two multicentre, multinational, randomised, double blind, controlled clinical trials are reviewed.