Novel inhibitors of inosine monophosphate dehydrogenase in patent literature of the last decade

• Published in: Recent patents on anti-cancer drug discovery Vol. 8; no. 2; p. 103
• Main Authors: Petrelli, Riccardo, Vita, Patrizia, Torquati, Ilaria, Felczak, Krzysztof, Wilson, Daniel J, Franchetti, Palmarisa, Cappellacci, Loredana
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 01-05-2013
• Subjects: Animals; Antineoplastic Agents - pharmacology; Antineoplastic Agents - therapeutic use; Antiparasitic Agents - pharmacology; Antiparasitic Agents - therapeutic use; Antiviral Agents - pharmacology; Antiviral Agents - therapeutic use; Drug Design; Drug Industry - legislation & jurisprudence; Enzyme Inhibitors - pharmacology; Enzyme Inhibitors - therapeutic use; Humans; Immunosuppressive Agents - pharmacology; Immunosuppressive Agents - therapeutic use; IMP Dehydrogenase - antagonists & inhibitors; Patents as Topic - statistics & numerical data
• ISSN: 2212-3970
• DOI: 10.2174/1574892811308020001

Inosine monophosphate dehydrogenase (IMPDH), an NAD-dependent enzyme that controls de novo synthesis of guanine nucleotides, has received considerable interest in recent years as an important target enzyme, not only for the discovery of anticancer drugs, but also for antiviral, antiparasitic, and immunosuppressive chemotherapy. The field of IMPDH inhibitor research is highly important for providing potential therapeutics against a validated target for disease intervention. This patent review examines the chemical structures and biological activities of recently reported IMPDH inhibitors. Patent databases SciFinder and Espacenet and Delphion were used to locate patent applications that were published between January 2002 and July 2012, claiming chemical structures for use as IMPDH inhibitors. From 2002 to 2012, around 47 primary patent applications have claimed IMPDH inhibitors, which we analyzed by target and applicant. The level of newly published patent applications covering IMPDH inhibitors remains high and a diverse range of scaffolds has been claimed.