Do alpha-acyloxy and alpha-alkoxycarbonyloxy radicals fragment to form acyl and alkoxycarbonyl radicals?
The generation of alpha-acyloxy and alpha-alkoxycarbonyloxy radicals under reductive conditions in fragmentable probe experiments does not provide unequivocal evidence for the fragmentation of such radicals to give ketones and acyl or alkoxycarbonyl radicals. Instead, standard reduction predominates...
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| Published in: | Beilstein journal of organic chemistry Vol. 2; no. 1; p. 10 |
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| Main Authors: | , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Germany
BioMed Central Ltd
25-05-2006
Beilstein-Institut |
| Subjects: | |
| Online Access: | Get full text |
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| Summary: | The generation of alpha-acyloxy and alpha-alkoxycarbonyloxy radicals under reductive conditions in fragmentable probe experiments does not provide unequivocal evidence for the fragmentation of such radicals to give ketones and acyl or alkoxycarbonyl radicals. Instead, standard reduction predominates, even at low tin hydride concentrations. Some ketone product is formed in the alpha-acyloxy substrate at low concentrations, but it is unclear whether this product arises through a slow radical fragmentation process or an inefficient, chain-breaking oxidative process. |
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| Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ISSN: | 1860-5397 1860-5397 |
| DOI: | 10.1186/1860-5397-2-10 |