Chlamydia pneumoniae and atherosclerosis

• Published in: Heart Vol. 81; no. 3; pp. 232 - 238
• Main Authors: Wong, Y-K, Gallagher, P J, Ward, M E
• Format: Journal Article Book Review
• Language: English
• Published: London BMJ Publishing Group Ltd and British Cardiovascular Society 01-03-1999; BMJ; BMJ Publishing Group LTD
• Subjects: Acute coronary syndromes; Acute Disease; Age; Animals; Antibiotics; Arteriosclerosis - microbiology; Atherosclerosis; Atherosclerosis (general aspects, experimental research); Bibliographic data bases; Biological and medical sciences; Blood and lymphatic vessels; Blood Vessels - microbiology; Cardiology. Vascular system; Cardiovascular disease; Chlamydia; Chlamydia Infections - complications; Chlamydophila pneumoniae - pathogenicity; Chronic Disease; Coronary Disease - microbiology; Coronary vessels; Deoxyribonucleic acid; DNA; Heart failure; Heat shock proteins; Humans; Immunoglobulins; Infections; Medical research; Medical sciences; Population; Rabbits; Review; Studies; Taiwan; Infection; Vascular disease; Human; Chlamydia pneumoniae; Chlamydiaceae; Pathogenesis; Atherosclerosis; Chlamydiales; Cardiovascular disease; Bacteria; Bibliographic review
• ISSN: 1355-6037; 1468-201X
• DOI: 10.1136/hrt.81.3.232

OBJECTIVE To review the literature for evidence that chronic infection withChlamydia pneumoniae is associated with atherosclerosis and acute coronary syndromes. DATA SOURCES medline and Institute of Science and Information bibliographic databases were searched at the end of September 1998. Indexing terms used were chlamydi*, heart, coronary, and atherosclerosis. Serological and pathological studies published as papers in any language since 1988 or abstracts since 1997 were selected. DATA EXTRACTION It was assumed that chronic C pneumoniae infection is characterised by the presence of both specific IgG and IgA, and serological studies were examined for associations that fulfilled these criteria. Pathological studies were also reviewed for evidence that the presence of C pneumoniae in diseased vessels is associated with the severity and extent of atherosclerosis. DATA SYNTHESIS The majority of serological studies have shown an association between C pneumoniaeand atherosclerosis. However, the number of cases in studies that have reported a positive association when using strict criteria for chronic infection is similar to the number of cases in studies which found no association. Nevertheless, the organism is widely found in atherosclerotic vessels, although it may not be at all diseased sites and is not confined to the most severe lesions. Rabbit models and preliminary antibiotic trials suggest that the organism might exacerbate atherosclerosis. CONCLUSION More evidence is required before C pneumoniae can be accepted as playing a role in atherosclerosis. Although use of antibiotics in routine practice is not justified, large scale trials in progress will help to elucidate the role of C pneumoniae.