Comparative Nephrotoxicity of Aspirin and Phenacetin Derivatives

• Published in: British Medical Journal Vol. 4; no. 5786; pp. 518 - 521
• Main Authors: Calder, I. C., Funder, C. C., Green, C. R., Ham, K. N., Tange, J. D.
• Format: Journal Article
• Language: English
• Published: England British Medical Journal Publishing Group 27-11-1971; British Medical Association; BMJ Publishing Group LTD
• Subjects: Aniline Compounds; Animals; Aspirin - toxicity; Dosage; Female; Hydroxyls; Intravenous injections; Kidney - drug effects; Kidney - pathology; Kidney Diseases - chemically induced; Kidney papillary necrosis; Kidney Papillary Necrosis - chemically induced; Kidney Tubules - pathology; Lesions; Necrosis; Nephrotoxicity; Papers and Originals; Papillae; Phenacetin - toxicity; Phenols; Proximal tubules; Rats; Sodium; Structure-Activity Relationship
• ISSN: 0007-1447; 1468-5833
• DOI: 10.1136/bmj.4.5786.518

Both aspirin and phenacetin derivatives were shown to be nephrotoxic when administered to rats as a single intravenous injection. Phenacetin derivatives tended to produce more severe renal damage and to be nephrotoxic in smaller doses than aspirin derivatives. With the exception of a single derivative, the renal lesions were confined to the proximal convoluted tubule, even after administration of compounds which under other conditions have induced renal papillary necrosis.