Influence of infant feeding and gluten intake on coeliac disease

• Published in: Archives of disease in childhood Vol. 76; no. 2; pp. 113 - 117
• Main Authors: Ascher, H, Krantz, I, Rydberg, L, Nordin, P, Kristiansson, B
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health 01-02-1997; BMJ; BMJ Publishing Group LTD; BMJ Group
• Subjects: Adolescent; Age; Age Factors; Baby foods; Biological and medical sciences; Breast Feeding; Case-Control Studies; Celiac disease; Celiac Disease - etiology; Celiac Disease - genetics; Child; Child, Preschool; coeliac disease; Constipation; Developmental Delays; Environmental Influences; Families & family life; Family (Sociological Unit); Female; Gastroenterology. Liver. Pancreas. Abdomen; Gluten; gluten consumption; Glutens - administration & dosage; Haplotypes; Histocompatibility Testing; HLA alleles; Humans; Infant; infant feeding habits; Infant Nutritional Physiological Phenomena; Infants; Male; Medical sciences; Original; Other diseases. Semiology; Patients; Risk Factors; Siblings; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Young Children; Sweden; Human; Immunopathology; Diet; Intestinal malabsorption; Food intake; Risk factor; Digestive diseases; Intestinal disease; Infant; Coeliac disease; Gluten; Feeding
• ISSN: 0003-9888; 1468-2044
• DOI: 10.1136/adc.76.2.113

OBJECTIVES To study the impact of infant feeding habits and actual gluten intake on gluten induced enteropathy. METHODS A case-referent design, controlling for the HLA alleles conferring increased genetic risk, was used. All 164 siblings of 97 probands were investigated. Eighty five of the siblings, carrying the genes DQA1*0501-DQB1*02 conferring susceptibility for the disease, were investigated by interview, food recording, and taking a small intestinal biopsy sample. Eight cases of silent coeliac disease were found and these were compared with the 73 siblings in whom the diagnosis was excluded. RESULTS No statistically significant differences were found between cases and referents in terms of duration of breast feeding, age at introduction of cows’ milk products, frequency of breast feeding after gluten introduction, and gluten consumption. CONCLUSIONS The studied factors may be of less importance for the development of gluten induced enteropathy.