Peutz-Jeghers polyps, dysplasia, and K-ras codon 12 mutations

Background—Peutz-Jeghers syndrome (PJS) is a rare, autosomal dominant, polyposis syndrome, associated with an increased risk of gastrointestinal and extragastrointestinal malignancy. Occasionally dysplasia occurs in PJS polyps. Aims—In colorectal carcinomas, mutations in codon 12 of the K-ras oncoge...

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Published in:Gut Vol. 41; no. 3; pp. 320 - 322
Main Authors: Entius, M M, Westerman, A M, Giardiello, F M, van Velthuysen, M-L F, Polak, M M, Slebos, R J C, Wilson, J H P, Hamilton, S R, Offerhaus, G J A
Format: Journal Article
Language:English
Published: London BMJ Publishing Group Ltd and British Society of Gastroenterology 01-09-1997
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Summary:Background—Peutz-Jeghers syndrome (PJS) is a rare, autosomal dominant, polyposis syndrome, associated with an increased risk of gastrointestinal and extragastrointestinal malignancy. Occasionally dysplasia occurs in PJS polyps. Aims—In colorectal carcinomas, mutations in codon 12 of the K-ras oncogene are common and are found at similar frequency in precursor adenomas. Therefore, K-rascodon 12 point mutations in PJS polyps were evaluated. Materials and methods—Fifty two PJS polyps, including four with dysplasia, collected from 19 patients with PJS, were analysed for mutations in the K-ras codon 12 by a mutant enriched polymerase chain reaction procedure, followed by allele specific oligodeoxynucleotide hybridisation. Results—A K-ras codon 12 mutation was identified in one colonic polyp with dysplasia. The mutation was found in the non-neoplastic epithelial cells and not in the dysplastic component of the polyp. Conclusions—K-ras codon 12 point mutations are very rare in PJS polyps, by contrast with colorectal adenomas. The findings support previous evidence that there seems to be no intrinsic relation between K-ras codon 12 mutation and dysplasia.
Bibliography:Professor Dr G J A Offerhaus, Department of Pathology, Academic Medical Centre, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
PMID:9378385
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ISSN:0017-5749
1468-3288
1458-3288
DOI:10.1136/gut.41.3.320