Peutz-Jeghers polyps, dysplasia, and K-ras codon 12 mutations
Background—Peutz-Jeghers syndrome (PJS) is a rare, autosomal dominant, polyposis syndrome, associated with an increased risk of gastrointestinal and extragastrointestinal malignancy. Occasionally dysplasia occurs in PJS polyps. Aims—In colorectal carcinomas, mutations in codon 12 of the K-ras oncoge...
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Published in: | Gut Vol. 41; no. 3; pp. 320 - 322 |
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Main Authors: | , , , , , , , , |
Format: | Journal Article |
Language: | English |
Published: |
London
BMJ Publishing Group Ltd and British Society of Gastroenterology
01-09-1997
BMJ BMJ Publishing Group LTD |
Subjects: | |
Online Access: | Get full text |
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Summary: | Background—Peutz-Jeghers syndrome (PJS) is a rare, autosomal dominant, polyposis syndrome, associated with an increased risk of gastrointestinal and extragastrointestinal malignancy. Occasionally dysplasia occurs in PJS polyps. Aims—In colorectal carcinomas, mutations in codon 12 of the K-ras oncogene are common and are found at similar frequency in precursor adenomas. Therefore, K-rascodon 12 point mutations in PJS polyps were evaluated. Materials and methods—Fifty two PJS polyps, including four with dysplasia, collected from 19 patients with PJS, were analysed for mutations in the K-ras codon 12 by a mutant enriched polymerase chain reaction procedure, followed by allele specific oligodeoxynucleotide hybridisation. Results—A K-ras codon 12 mutation was identified in one colonic polyp with dysplasia. The mutation was found in the non-neoplastic epithelial cells and not in the dysplastic component of the polyp. Conclusions—K-ras codon 12 point mutations are very rare in PJS polyps, by contrast with colorectal adenomas. The findings support previous evidence that there seems to be no intrinsic relation between K-ras codon 12 mutation and dysplasia. |
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Bibliography: | Professor Dr G J A Offerhaus, Department of Pathology, Academic Medical Centre, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands. PMID:9378385 istex:AE255D103B700A421802340315E521978AE7466D href:gutjnl-41-320.pdf ark:/67375/NVC-139NS061-8 local:gutjnl;41/3/320 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0017-5749 1468-3288 1458-3288 |
DOI: | 10.1136/gut.41.3.320 |