Triiodothyroacetic acid in health and disease

• Published in: Journal of endocrinology Vol. 234; no. 2; pp. R99 - R121
• Main Authors: Groeneweg, Stefan, Peeters, Robin P, Visser, Theo J, Visser, W Edward
• Format: Journal Article
• Language: English
• Published: England Bioscientifica Ltd 01-08-2017; Portland Press Ltd The Biochemical Society
• Subjects: Animals; Basal Metabolism - physiology; Biological Transport - physiology; Humans; Hypothalamo-Hypophyseal System - physiology; Metabolism; Receptors, Thyroid Hormone - metabolism; Review; Therapeutic applications; Thyroid; Thyroid Gland - physiology; Transcription activation; Triiodothyronine; Triiodothyronine - analogs & derivatives; Triiodothyronine - metabolism; Triiodothyronine - pharmacology; Triac; thyroacetic acid derivatives; thyroid hormone analog; thyroid hormone; resistance to thyroid hormone (RTH); TA3
• ISSN: 0022-0795; 1479-6805
• DOI: 10.1530/JOE-17-0113

Thyroid hormone (TH) is crucial for development and metabolism of many tissues. The physiological relevance and therapeutic potential of TH analogs have gained attention in the field for many years. In particular, the relevance and use of 3,3′,5-triiodothyroacetic acid (Triac, TA3) has been explored over the last decades. Although TA3 closely resembles the bioactive hormone T3, differences in transmembrane transport and receptor isoform-specific transcriptional activation potency exist. For these reasons, the application of TA3 as a treatment for resistance to TH (RTH) syndromes, especially MCT8 deficiency, is topic of ongoing research. This review is a of all currently available literature about the formation, metabolism, action and therapeutic applications of TA3.