Involvement of Regional Lymph Nodes after Penetration of Schistosoma mansoni Cercariae in Naive and Infected Mice

• Published in: Memórias do Instituto Oswaldo Cruz Vol. 91; no. 4; pp. 491 - 498
• Main Authors: Lozzi, S P, Machado, C R, Gerken, S E, Mota-Santos, T A
• Format: Journal Article
• Language: English
• Published: Brazil Fundação Oswaldo Cruz, Fiocruz 01-08-1996; Instituto Oswaldo Cruz, Ministério da Saúde; Fundação Oswaldo Cruz (FIOCRUZ)
• Subjects: Animals; Cell Count; eosinophils; Eosinophils - immunology; high endothelial venules; Immunity, Cellular; lymph nodes; Lymph Nodes - immunology; Lymph Nodes - parasitology; Lymph Nodes - pathology; Male; mast cells; Mast Cells - immunology; Mice; Mice, Inbred BALB C; PARASITOLOGY; Parotid Gland - immunology; Parotid Gland - parasitology; Parotid Gland - pathology; Schistosoma mansoni; Schistosoma mansoni - immunology; Schistosoma mansoni - lymph nodes - schistosomulum migration - eosinophils - mast cells - high endothelial venules; Schistosomiasis - immunology; Schistosomiasis - parasitology; schistosomulum migration; TROPICAL MEDICINE; Schistosoma mansoni; eosinophils; lymph nodes; schistosomulum migration; mast cells; high endothelial venules
• ISSN: 1678-8060; 0074-0276; 0074-0276; 1678-8060
• DOI: 10.1590/S0074-02761996000400017

The parotid lymph nodes of naive and previously infected Balb/c mice
were studied after, respectively, infection and re-infection with
cercariae of Schistosoma mansoni via the ears. Schistosomula were able
to pass through the lymph node by following the lymph flow or by
penetrating the veins of the medullary cords. The number of nodal mast
cells was higher from day 2 to 6 of primary infection; and from day 5
to 11 of re-infection. The amount of degranulating mast cells was
significantly higher at day 4 of infection and at day 1 of re-
infection. Eosinophils characterized the nodal inflammatory processes
observed after day 5 in both primarily-infected and re-infected mice.
However, only in the latter the eosinophils were able to adhere to the
larval surface. In primarily- infected mice, no intranodal larva
presented signs of degeneration. In contrast, in re-infected animals,
some degenerating larvae were found inside eosinophilic infiltrates.
The eosinophils reached the nodal tissue by migrating through the high
endothelial venules and their collecting veins.