Cross-sectional analysis of retrospective case series of hospitalisations for gastropathy caused by non-steroidal anti-inflammatory treatment: risk factors and gastroprotection use

• Published in: European journal of hospital pharmacy. Science and practice Vol. 24; no. 6; pp. 355 - 360
• Main Authors: Marco Garbayo, José Luis, Koninckx Cañada, Manuel, Pérez Castelló, Isabel, Faus Soler, María Teresa, Fuster Torres, Rosa, Moncho Escrivà, Mar
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group LTD 01-11-2017; BMJ Publishing Group
• Subjects: Age; Anticoagulants; Aspirin; Cross-sectional studies; Drug dosages; Drug therapy; Hospitals; Laboratories; Mens health; Nonsteroidal anti-inflammatory drugs; Original; Patient safety; Risk factors; Studies; Ulcers; Womens health; Borja Spain; Spain
• ISSN: 2047-9956; 2047-9964
• DOI: 10.1136/ejhpharm-2016-001087

ObjectivesTo analyse the risk factors of gastropathy caused by using non-steroidal anti-inflammatory drugs (NSAIDs) in detected hospital admissions and to analyse the use of gastroprotective treatment concerning these risk factors.MethodsA retrospective observational study was carried out in the framework of an integral risk management plan of drugs and proactive pharmacovigilance of hospital admissions for NSAID-induced gastropathy occurring between 2011 and 2015. Cases were identified after reviewing the ICD-9 codes related to NSAID-induced gastropathy in hospital discharge reports. Various biometric, clinical and pharmacotherapeutic variables of each patient were registered. The gastroprotective criteria set out in the therapeutic decision algorithm of the Valencian Health System were followed.Results62 hospital admissions for NSAID-induced gastropathy were detected. The mean length of stay was 5.3±3.8 days. Ibuprofen was the most prevalent NSAID (28 cases, 45.2%). 24 cases (38.7%) took NSAIDs in the week before hospitalisation. The prevalence of relevant risk factors for gastropathy were age >60 years (37 cases, 59.7%), concomitant medication (24 cases, 38.7%) and a history of peptic ulcer (9 cases, 14.5%). 41 patients (66.1%) met gastroprotective major criteria, 18 of whom (43.9%) were using a proton pump inhibitor following a prevention plan.ConclusionsIn this study all relevant gastroprotective criteria were associated with the use of gastroprotection in detected hospital admissions for NSAID-induced gastropathy. However, a lack of gastroprotection was observed in a large number of detected cases with the criteria to use it. The feedback of our results to health area agents can serve to reinforce the safe use of NSAIDs.