Light and electron microscopical studies of focal glomerular sclerosis

Renal biopsy material from seven cases of the nephrotic syndrome due to focal glomerular sclerosis has been studied by light, electron, and immunofluorescent microscopy. The nature of glomerular basement membrane changes and the scar tissue was also studied. It was found that the glomerular basement...

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Bibliographic Details
Published in:	Journal of clinical pathology Vol. 24; no. 9; pp. 846 - 850
Main Authors:	Nagi, A. H., Alexander, F., Lannigan, R.
Format:	Journal Article
Language:	English
Published:	England BMJ Publishing Group Ltd and Association of Clinical Pathologists 01-12-1971 BMJ Publishing Group LTD
Subjects:	Adolescent Adult Basement Membrane - pathology Biopsy Child Fluorescent Antibody Technique Humans Kidney Glomerulus - pathology Microscopy, Electron Microscopy, Fluorescence Nephrotic Syndrome - pathology Sclerosis - pathology
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Summary:	Renal biopsy material from seven cases of the nephrotic syndrome due to focal glomerular sclerosis has been studied by light, electron, and immunofluorescent microscopy. The nature of glomerular basement membrane changes and the scar tissue was also studied. It was found that the glomerular basement membrane and mesangial matrix formed the major components of scar tissue. On the basis of a short history in some of our cases, a poor response to steroid therapy in the early stages, and the distinct morphological changes, it is suggested that focal glomerular sclerosis has an independent origin and is not a stage of minimal change lesion.
Bibliography:	local:jclinpath;24/9/846 PMID:4946418 istex:5A4FBEBE1C9257E987521F1C80BB57892521AC9F href:jclinpath-24-846.pdf ark:/67375/NVC-FVH4ZF9J-2 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0021-9746 1472-4146
DOI:	10.1136/jcp.24.9.846