They Must Hold Tight: Junction Proteins, Microbiota And Immunity In Intestinal Mucosa

• Published in: Current protein & peptide science Vol. 16; no. 7; p. 655
• Main Authors: Castoldi, Angela, Favero de Aguiar, Cristhiane, Moraes-Vieira, Pedro Manoel, Olsen Saraiva Câmara, Niels
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 01-01-2015
• Subjects: Adaptive Immunity; Animals; Epithelial Cells - metabolism; Gastrointestinal Microbiome; Humans; Inflammatory Bowel Diseases - metabolism; Inflammatory Bowel Diseases - microbiology; Intestinal Mucosa - metabolism; Intestinal Mucosa - microbiology; Intestinal Mucosa - pathology; Permeability; T-Lymphocytes - immunology; Tight Junctions - metabolism; Toll-Like Receptors - metabolism
• ISSN: 1875-5550
• DOI: 10.2174/1389203716666150630133141

Homeostasis of the immune system depends on several factors. The gastrointestinal tract plays an important role in maintaining our immune system. With this aim, the intestinal immune system interacts with epithelial barrier molecules, especially tight junction proteins, that are key molecules involved in controlling paracellular permeability to increase the protection barrier against external antigens or possibly to respond to commensal microorganisms. During intestinal inflammatory diseases, the expression of innate immune receptors in intestinal epithelial cells and infiltration of immune cells are related, but it is still unclear how the immune system induces modulation of paracellular permeability. In this review, we provide an overview of the understanding of how the immune system modulates the expression of tight junctions to maintain the mucosal immune system.