Results from a retrospective analysis of colonoscopies for Inflammatory bowel disease and colorectal cancer in a Lebanese tertiary care centre

• Published in: BMJ open gastroenterology Vol. 4; no. 1; p. e000167
• Main Authors: Saber, Toufic, Bedran, Khalil, Ghandour, Fatima, El Khoury, Mansour, Bou Khalil, Roula, Farhat, Said
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group LTD 2017; BMJ Publishing Group
• Subjects: Colon; Colorectal cancer; Health risk assessment; Inflammatory bowel disease; Mortality; Pathology; Polyps; Systematic review; Lebanon; adenocarcinoma; ibd; colonic diseases
• ISSN: 2054-4774; 2054-4774
• DOI: 10.1136/bmjgast-2017-000167

Background and aimsInflammatory bowel diseases (IBDs) and colorectal cancer have an increased impact on the Lebanese population’s morbidity and mortality. This study evaluated the situation of IBD and colorectal cancer at a tertiary hospital centre in Lebanon.Methods1007 patients underwent colonoscopy over a period of 12 months by qualified physicians. 91 patients were excluded from the study. Biopsy results were divided into normal versus abnormal colonic tissue. The abnormal section was further subdivided into number of polyps, IBD, dysplasia and cancer.ResultsOut of 916 individuals included, 61 cases of Crohn’s colitis (CC) (6.7%) and 24 cases of ulcerative colitis (UC) (2.7%) were identified. A total of 92 cases of colorectal cancer (10.04%) were also identified. There was a slight male predominance in both groups of IBD without any statistical significance. One statistical significance was reported in favour to age<50 years in both IBD groups with a mean age of 37.9±9.7 years and 34.4±6.4 years for CC and UC, respectively. The incidence of granuloma in the CC group was 8.9% without any correlation compared with age or gender. No correlation was made between colorectal cancer and the existence of any IBD type. The data showed that age >50 years and male gender significantly correlate with an increased incidence of precancerous and cancerous polyps in the colon. They significantly correlate with adenocarcinoma. The estimated incidence of colorectal cancer, CC and UC was 54.1, 35.8 and 14.1 per 100 000, respectively, with a denominator of 169 959 patients per year.ConclusionWithin the limitations of this study, the incidence of colorectal cancer and IBD falls in the high range compared with similar European and American studies. Our data are biased because of the tertiary centre setting but they can be considered as base for further investigations.