Role of Exosomes in Photodynamic Anticancer Therapy

• Published in: Current medicinal chemistry Vol. 27; no. 40; p. 6815
• Main Authors: Jiang, Yuan, Xu, Chuanshan, Leung, Wingnang, Lin, Mei, Cai, Xiaowen, Guo, Huanhuan, Zhang, Jiyong, Yang, Fanwen
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 01-01-2020
• Subjects: Exosomes; Humans; Neoplasms - drug therapy; Photochemotherapy; Photosensitizing Agents - therapeutic use; Photodynamic therapy; tumor metastasis; tumor microenvironment; tumor drug resistance; exosomes; tumor
• ISSN: 1875-533X
• DOI: 10.2174/0929867326666190918122221

Photodynamic Therapy (PDT) is a promising alternative treatment for malignancies based on photochemical reaction induced by Photosensitizers (PS) under light irradiation. Recent studies show that PDT caused the abundant release of exosomes from tumor tissues. It is well-known that exosomes as carriers play an important role in cell-cell communication through transporting many kinds of bioactive molecules (e.g. lipids, proteins, mRNA, miRNA and lncRNA). Therefore, to explore the role of exosomes in photodynamic anticancer therapy has been attracting significant attention. In the present paper, we will briefly introduce the basic principle of PDT and exosomes, and focus on discussing the role of exosomes in photodynamic anticancer therapy, to further enrich and boost the development of PDT.