Relationship of anthropometric measurements to thyroid nodules in a Chinese population

• Published in: BMJ open Vol. 5; no. 12; p. e008452
• Main Authors: Xu, Weimin, Chen, Zexin, Li, Na, Liu, Hui, Huo, Liangliang, Huang, Yangmei, Jin, Xingyi, Deng, Jin, Zhu, Sujuan, Zhang, Shanchun, Yu, Yunxian
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group LTD 21-12-2015; BMJ Publishing Group
• Subjects: Adolescent; Adult; Age groups; Alcohol; Asian Continental Ancestry Group; Body Height; Body Mass Index; Cancer; Child; China - epidemiology; Clinical medicine; Cross-Sectional Studies; Developing countries; Disease Susceptibility; Epidemiology; Families & family life; Female; Gender; Households; Humans; Incidence; LDCs; Male; Metabolism; Obesity; Obesity - complications; Obesity - epidemiology; Overweight; Population; Risk Factors; Smoking; Thyroid gland; Thyroid Gland - diagnostic imaging; Thyroid Gland - pathology; Thyroid Neoplasms - epidemiology; Thyroid Neoplasms - pathology; Thyroid Neoplasms - prevention & control; Thyroid Nodule - diagnostic imaging; Thyroid Nodule - epidemiology; Thyroid Nodule - pathology; Ultrasonography; China; STATISTICS & RESEARCH METHODS; EPIDEMIOLOGY
• ISSN: 2044-6055; 2044-6055
• DOI: 10.1136/bmjopen-2015-008452

ObjectivePrevious studies have found that overweight and obesity are related to numerous diseases, including thyroid cancer and thyroid volume. This study evaluates the relationship between body size and the presence of thyroid nodules in a Chinese population.MethodsA total of 6793 adults and 2410 children who underwent thyroid ultrasonography were recruited in this cross-sectional study in Hangzhou, Zhejiang Province, China, from March to October, 2010. Sociodemographic characteristics and potential risk factors of thyroid nodules were collected by questionnaire. Height and weight were measured using standard protocols. Associations of height, weight, body mass index (BMI) and body surface area (BSA) with the presence of thyroid nodules were evaluated using multiple logistic regression models.ResultsAfter adjustment for potential risk factors, an increased risk of thyroid nodule incidence was associated with height (OR 1.15, 95% CI 1.02 to 1.30), weight (OR 1.40, 95% CI 1.24 to 1.58), BMI (OR 1.26, 95% CI 1.11 to 1.42) and BSA (OR 1.43, 95% CI 1.27 to 1.62) in all adults, but most obviously in women. In children, similar associations were observed between risk of thyroid nodule incidence and weight, BMI and BSA, but not height. BSA was the measurement most significantly associated with thyroid nodules in both adults and children.ConclusionsThis study identified that the presence of thyroid nodules was positively associated with weight, height, BMI and BSA in both women and girls. It suggests that tall, obese individuals have increased susceptibility to thyroid nodules.Trial registration number:NCT01838629.