Phyto-Phospholipid Complexation as a Novel Drug Delivery System for Management of Cancer with Better Bioavailability: Current Perspectives and Future Prospects

• Published in: Anti-cancer agents in medicinal chemistry Vol. 21; no. 11; p. 1403
• Main Authors: Sahu, Ram K, Aboulthana, Wael M, Mehta, Dinesh K
• Format: Journal Article
• Language: English
• Published: Netherlands 01-01-2021
• Subjects: Antineoplastic Agents - chemistry; Antineoplastic Agents - metabolism; Antineoplastic Agents - pharmacology; Biological Availability; Cell Proliferation - drug effects; Cell Survival - drug effects; Drug Delivery Systems; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Phospholipids - chemistry; Phospholipids - metabolism; Phospholipids - pharmacology; Phytochemicals - chemistry; Phytochemicals - metabolism; Phytochemicals - pharmacology; limitation; cancer; application; bioavailability; plant active; Phyto-phospholipid complexes
• ISSN: 1875-5992
• DOI: 10.2174/1871520620999201110191741

Cancer is the foremost cause of death, and it supports the need for the identification of novel anticancer drugs to improve the efficacy of current-therapy. While the synthetic anticancer drug is associated with numerous side effects. Hence the plant active or phytoconstituents are in high demand for the treatment of cancer due to minimum side effects. But the polar nature of phytoconstituents hindered the absorption of the drug and lowered the therapeutic efficacy. The plant activity incorporated into Phyto-phospholipid Complexation can enhance bioavailability and improved therapeutic efficacy. In this review article, advantages, limitation and application of Phyto-phospholipid complexes have been illustrated. The article highlights the application of Phyto-phospholipid complexes as a promising drug carrier system to treat cancer.