RENEWED HOPE FOR A VACCINE AGAINST THE INTESTINAL ADULT TAENIA SOLIUM

• Published in: The Journal of parasitology Vol. 93; no. 4; pp. 824 - 831
• Main Authors: Sciutto, Edda, Rosas, Gabriela, Cruz-Revilla, Carmen, Toledo, Andrea, Cervantes, Jacquelynne, Hernández, Marisela, Hernández, Beatríz, Goldbaum, Fernando A, de Aluja, Aline S, Fragoso, Gladis, Larralde, Carlos
• Format: Journal Article
• Language: English
• Published: Lawrence, KS American Society of Parasitologists 01-08-2007; Allen Press Inc
• Subjects: adult tapeworms; Animals; Anthelmintics - therapeutic use; anticestode vaccines; Antigens; Biological and medical sciences; Carrier State - drug therapy; Carrier State - prevention & control; Cestoda; Cysticercosis; Defecation; disease control; Disease prevention; Eggs; Fundamental and applied biological sciences. Psychology; General aspects; General aspects and techniques. Study of several systematic groups. Models; Hogs; Humans; immunity; IMMUNOLOGY; Infections; Intestinal Diseases, Parasitic - prevention & control; Intestine; intestines; Invertebrates; Parasite hosts; Parasites; Parasitic diseases; Parasitology; Personal health; protective effect; Rural areas; Taenia solium; Taenia solium - immunology; Taeniasis; Taeniasis - drug therapy; Taeniasis - prevention & control; Tapeworms; Transplantation immunology; Vaccination; vaccine development; Vaccines; Helmintha; Plathelmintha; Parasite; Vaccine; Cestoda; Invertebrata; Taenia solium
• ISSN: 0022-3395; 1937-2345
• DOI: 10.1645/GE-1018R1.1

Review of experimental and observational evidence about various cestode infections of mammalian hosts revives hope for the development of an effective vaccine against adult intestinal tapeworms, the central protagonists in their transmission dynamics. As for Taenia solium, there are abundant immunological data regarding cysticercosis in humans and pigs, but information about human taeniasis is scarce. A single publication reporting protection against T. solium taeniasis by experimental primo infection and by vaccination of an experimental foster host, the immunocompetent female hamster, kindles the hope of a vaccine against the tapeworm to be used in humans, its only natural definitive host.