Electroretinographic findings in retinal vasculitis

• Published in: British journal of ophthalmology Vol. 107; no. 12; p. 1834
• Main Authors: Ghoraba, Hashem H, Matsumiya, Wataru, Or, Christopher, Khojasteh, Hassan, Patel, Prem, Karaca, Irmak, Regenold, Jonathan, Zaidi, Moosa, Hwang, Jaclyn, Lajevardi, Sherin, Yavari, Negin, Than, Ngoc Trong Tuong, Park, Sung Who, Akhavanrezayat, Amir, Uludag, Gunay, Yasar, Cigdem, Leung, Loh-Shan B, Nguyen, Quan Dong
• Format: Journal Article
• Language: English
• Published: England 01-12-2023
• Subjects: Adult; Electroretinography; Female; Fluorescein Angiography; Humans; Male; Middle Aged; Retina - diagnostic imaging; Retinal Cone Photoreceptor Cells; Retinal Vasculitis - diagnosis; Young Adult; electrophysiology; inflammation; retina
• ISSN: 1468-2079
• DOI: 10.1136/bjo-2022-321716

To describe and correlate electroretinographic responses with clinical and angiographic findings in retinal vasculitis (RV).
Medical records of patients with diagnosis of RV at a tertiary eye centre from December 2017 to May 2021 were reviewed. Cases in which fluorescein angiography (FFA) and full field electroretinography (ffERG) were done within 1 month were included. FFAs were graded according to the Angiography Scoring for Uveitis Working Group from 0 to 40, where 0 is normal. A novel ffERG grading system was implemented where individual waves were graded for timing and amplitude and general ffERG score was determined with 6 being a perfect score.
20 patients (34 eyes) were included. Mean age was 43.9±19.8 years; 70% were female. Median best-corrected visual acuity was 0.8 (0.08-1). Mean FFA score was 12.6±6.5. Median general ffERG score was 5 (0-6). 68% and 91% of eyes had responses with general ffERG scores ≥5 and 4, respectively. Flicker timing was most commonly affected.FFA scores weakly correlated with delayed photopic cone b-wave and flicker timing (p=0.03 and 0.016, respectively). Vitreous haze moderately correlated with delayed cone b-wave timing (p<0.001), delayed flicker timing (p=0.002) and weakly correlated with lower flicker amplitude (p=0.03). Underlying systemic disease was associated with poor ffERG responses.
In this study, RV was not frequently associated with severe global retinal dysfunction Higher FFA scores, and vitreous haze grading were weakly, but significantly, correlated with cone-generated ffERG responses.