Hematopoietic cell formation in leech wound healing

The angiogenic process in vertebrates and hirudineans has been compared. The leech Hirudo medicinalis, subjected to an angiogenic stimulus (surgical explant or cytokine treatment) responds, as a vertebrate, with the formation of an extensive network of new vessels accompanied by the production of ci...

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Bibliographic Details
Published in:	Current pharmaceutical design Vol. 12; no. 24; p. 3033
Main Authors:	Grimaldi, A, Tettamanti, G, Perletti, G, Valvassori, R, de Eguileor, M
Format:	Journal Article
Language:	English
Published:	United Arab Emirates 01-08-2006
Subjects:	Animals Hematopoiesis - physiology Hirudo medicinalis - physiology Humans Models, Animal Vertebrates - physiology Wound Healing - physiology
Online Access:	Get more information
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Summary:	The angiogenic process in vertebrates and hirudineans has been compared. The leech Hirudo medicinalis, subjected to an angiogenic stimulus (surgical explant or cytokine treatment) responds, as a vertebrate, with the formation of an extensive network of new vessels accompanied by the production of circulating cells. The reviewed data confirm the surprising similarity between hirudinean and vertebrate processes in wound healing, and suggest that basic common events such as antigenic expressions of endothelial and hemopoietic cells, cytokine secretion and regulation as well as extracellular matrix interactions, are conserved and extended across diverse species, tissues and developmental phases.
ISSN:	1381-6128
DOI:	10.2174/138161206777947443