Evidence for the presence of the pituitary insulin secretagogue beta-cell trophin in human plasma

It has been demonstrated that the insulin secretagogue beta-cell-trophin, ACTH(22-39), is present in human plasma. The hormone, separated from plasma by affinity chromatography on a corticotrophin-like intermediate-lobe peptide antibody column, behaves similarly to synthetic beta-cell-trophin on a g...

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Bibliographic Details
Published in:	Journal of endocrinology Vol. 110; no. 2; p. 303
Main Authors:	Salvatoni, A, Dunmore, S J, Morton, J L, Etienne, A T, Beloff-Chain, A, Abraham, R R
Format:	Journal Article
Language:	English
Published:	England 01-08-1986
Subjects:	Adrenocorticotropic Hormone - blood Adrenocorticotropic Hormone - pharmacology Animals Chromatography, Affinity Chromatography, Gel Chromatography, High Pressure Liquid Humans Insulin - metabolism Insulin Secretion Male Nelson Syndrome - blood Pancreas - drug effects Pancreas - metabolism Peptide Fragments - blood Peptide Fragments - pharmacology Perfusion Rats Rats, Inbred Strains
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Summary:	It has been demonstrated that the insulin secretagogue beta-cell-trophin, ACTH(22-39), is present in human plasma. The hormone, separated from plasma by affinity chromatography on a corticotrophin-like intermediate-lobe peptide antibody column, behaves similarly to synthetic beta-cell-trophin on a gel filtration column and on reverse-phase high-performance liquid chromatography. Sufficient amounts of the hormone were isolated from the plasma of two patients with Nelson's syndrome to demonstrate its biological activity on the perfused rat pancreas.
ISSN:	0022-0795
DOI:	10.1677/joe.0.1100303