P16-30. Induction of Tim-3 expression by the common gamma-chain cytokines IL-2, IL-7, IL-15 and IL-21

While expression is disproportionately high on HIV-1-specific CD8+ T cells, >70% of total CD8+ T cells in the peripheral blood of infected individuals have been observed to express Tim-3, suggesting the existence of a more general mechanism of induction. [...] Tim-3 may contribute not only to an...

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Bibliographic Details
Published in:	Retrovirology Vol. 6; no. Suppl 3; p. P259
Main Authors:	Jones, BR, Ostrowski, MA, Lo, CA, Mujib, S, Hunter, DV, Ndhlovu, LC, Nixon, DF
Format:	Journal Article
Language:	English
Published:	London BioMed Central 22-10-2009 BioMed Central Ltd BMC
Subjects:	Acquired immune deficiency syndrome AIDS Apoptosis Poster Presentation Vaccines
Online Access:	Get full text
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Summary:	While expression is disproportionately high on HIV-1-specific CD8+ T cells, >70% of total CD8+ T cells in the peripheral blood of infected individuals have been observed to express Tim-3, suggesting the existence of a more general mechanism of induction. [...] Tim-3 may contribute not only to an impairement of virus-specific responses, but also tp a more generalized immunosuppression.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1742-4690 1742-4690
DOI:	10.1186/1742-4690-6-S3-P259