Computer-aided drug design: lead discovery and optimization

Over the past decade, there have been remarkable advances in the area of computer-aided drug design (CADD), which has been applied at almost all stages in the drug discovery pipeline. The generation of initial lead compounds and the subsequent optimization aimed at improving potency and pharmacologi...

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Bibliographic Details
Published in:	Combinatorial chemistry & high throughput screening Vol. 15; no. 4; p. 328
Main Authors:	Xiang, Mingli, Cao, Yu, Fan, Wenjie, Chen, Lijuan, Mo, Yirong
Format:	Journal Article
Language:	English
Published:	United Arab Emirates 01-05-2012
Subjects:	Animals Computer-Aided Design Drug Design Humans Models, Molecular Pharmaceutical Preparations - chemistry Pharmacology Protein Conformation Proteins - chemistry Proteins - metabolism
Online Access:	Get more information
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Summary:	Over the past decade, there have been remarkable advances in the area of computer-aided drug design (CADD), which has been applied at almost all stages in the drug discovery pipeline. The generation of initial lead compounds and the subsequent optimization aimed at improving potency and pharmacological properties are the core activities among all. The development in these aspects over the past years will be the focus of this review.
ISSN:	1875-5402
DOI:	10.2174/138620712799361825