The complement cascade: new avenues in stroke therapy

Recent evidence has shown that after the initial occlusion, a large portion of stroke patients achieve some degree of reperfusion either through collateral circulation or clot dissolution. However, it appears that this reperfusion may lead to increased inflammation-induced damage. Even though the ex...

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Bibliographic Details
Published in:	Current vascular pharmacology Vol. 7; no. 3; p. 287
Main Authors:	Komotar, Ricardo J, Starke, Robert M, Arias, Eric J, Garrett, Matthew C, Otten, Marc L, Merkow, Maxwell B, Hassid, Benjamin, Mocco, J, Sughrue, Michael E, Kim, Grace H, Mack, William J, Ducruet, Andrew F, Connolly, E Sander
Format:	Journal Article
Language:	English
Published:	United Arab Emirates 01-07-2009
Subjects:	Animals Brain - physiopathology Complement Activation - drug effects Complement Activation - physiology Complement Inactivating Agents - therapeutic use Disease Models, Animal Humans Models, Biological Neurogenesis - drug effects Reperfusion Injury - drug therapy Reperfusion Injury - physiopathology Stroke - complications Stroke - drug therapy Stroke - physiopathology
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Summary:	Recent evidence has shown that after the initial occlusion, a large portion of stroke patients achieve some degree of reperfusion either through collateral circulation or clot dissolution. However, it appears that this reperfusion may lead to increased inflammation-induced damage. Even though the exact mechanism of this secondary injury is unclear, several experimental studies have indicated an intimate connection between complement and this secondary form of damage. We review the available literature and attempt to identify promising clinical therapeutic targets.
ISSN:	1570-1611
DOI:	10.2174/157016109788340677