Thyroid antibodies in blood donors: prevalence and clinical significance

• Published in: Acta endocrinologica (Copenhagen) Vol. 105; no. 3; p. 324
• Main Authors: Bjøro, T, Gaarder, P I, Smeland, E B, Kornstad, L
• Format: Journal Article
• Language: English
• Published: Denmark 01-03-1984
• Subjects: Adult; Antibodies - analysis; Autoantibodies - analysis; Blood Donors; Female; Goiter - diagnosis; Goiter - immunology; Humans; Hypothyroidism - diagnosis; Hypothyroidism - immunology; Male; Middle Aged; Thyroglobulin - immunology; Thyroid Function Tests; Thyroiditis - diagnosis; Thyroiditis - immunology
• ISSN: 0001-5598
• DOI: 10.1530/acta.0.1050324

In sera from 1643 randomly selected blood donors examined in 1979 thyroglobulin antibodies (TGA) were found in 3.4% and thyroid microsomal antibodies (TMA) in 7.0%. TMA, but not TGA, showed significant sex and age relationships. Eight-two donors with TMA titres greater than or equal to 1600 and/or TGA titres greater than or equal to 128 were available for a follow-up study in 1982. In 69 of these with TMA there was a significantly increased incidence of pathological thyroid function-test values (T4, T3 and TSH) as compared to age- and sexmatched donors without thyroid antibodies. In this group 9 individuals had overt and three latent hypothyroidism, two individuals were found with symptomless autoimmune thyroiditis and one with a non-toxic nodular goitre. Only 2 of these had been diagnosed before 1982, and none recognized before 1979. In addition, the group contained 9 individuals who had been treated because of hyperthyroidism, all except one before 1979. The likelihood of detecting a previously unrecognized hypothyroidism increased with increasing TMA titre. In contrast, the 24 donors with TGA did not show an increased frequency of pathological thyroid function-test-values in 1982.