The generation of disinhibition bursts of dopaminergic neurons in the basal ganglia

[...]in vivo we expect SNpc activity to depend on the neuron’s intrinsic pacemaking currents acting in tandem with tonic NMDA and GABAA-mediated synaptic currents. Striatal, pallidal, and pars reticulata evoked inhibition of nigrostriatal dopaminergic neurons is mediated by GABA(A) receptors in vivo...

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Bibliographic Details
Published in:	BMC neuroscience Vol. 11; no. S1; p. P112
Main Authors:	Lobb, Collin J, Paladini, Carlos A, Wilson, Charles J, Troyer, Todd W
Format:	Journal Article
Language:	English
Published:	London BioMed Central 20-07-2010 BioMed Central Ltd BMC
Subjects:	Basal ganglia Computational neuroscience Dopamine Dopamine receptors Glutamic acid receptors (ionotropic) N-Methyl-D-aspartic acid receptors Neostriatum Nervous system Neurons Poster Presentation Substantia nigra Subthalamic nucleus γ-Aminobutyric acid A receptors
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Summary:	[...]in vivo we expect SNpc activity to depend on the neuron’s intrinsic pacemaking currents acting in tandem with tonic NMDA and GABAA-mediated synaptic currents. Striatal, pallidal, and pars reticulata evoked inhibition of nigrostriatal dopaminergic neurons is mediated by GABA(A) receptors in vivo. Subthalamic nucleus modulates burst firing in nigral dopamine neurones via NMDA receptors.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Conference-3 SourceType-Conference Papers & Proceedings-2
ISSN:	1471-2202 1471-2202
DOI:	10.1186/1471-2202-11-S1-P112