Coagulation disorders in thyroid diseases

Introduction Various abnormalities of coagulation occur in patients with thyroid diseases, and may range from subclinical laboratory abnormalities to clinically significant disturbances of coagulation and, rarely, major hemorrhage or thromboembolism (1). Patients with hypothyroidism are at particula...

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Bibliographic Details
Published in:	European journal of endocrinology Vol. 136; no. 1; pp. 1 - 7
Main Authors:	HOFBAUER, L. C, HEUFELDER, A. E
Format:	Journal Article
Language:	English
Published:	Colchester Portland Press 01-01-1997
Subjects:	Animals Antiphospholipid Syndrome - physiopathology Antithyroid Agents - adverse effects Biological and medical sciences Blood Coagulation Disorders - etiology Blood Coagulation Disorders - therapy Endocrinopathies Graves Disease - physiopathology Humans Hyperthyroidism - complications Hypothyroidism - physiopathology Medical sciences Non tumoral diseases. Target tissue resistance. Benign neoplasms Purpura, Thrombocytopenic, Idiopathic - physiopathology REVIEWS Thromboembolism - etiology Thyroid Diseases - complications Thyroid Diseases - physiopathology Thyroid Neoplasms - physiopathology Thyroid. Thyroid axis (diseases) Endocrinopathy Human Association Clinical management Pathogenesis Hyperthyroidism Thyroid diseases Coagulation Complication Hemopathy Hypothyroidism Coagulopathy
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Summary:	Introduction Various abnormalities of coagulation occur in patients with thyroid diseases, and may range from subclinical laboratory abnormalities to clinically significant disturbances of coagulation and, rarely, major hemorrhage or thromboembolism (1). Patients with hypothyroidism are at particular risk of hemorrhage (2). In contrast, patients with hyperthyroidism display a tendency to develop thromboembolic complications, with major embolism accounting for up to 18% of deaths in patients dying from thyrotoxicosis (3). Pathogenesis of coagulopathies associated with thyroid diseases may include direct and indirect effects of excess or deficiency of thyroid hormones on platelet maturation and function, on synthesis and action of coagulation factors, and on altered blood viscosity (4). In addition, coagulopathies in patients with autoimmune thyroid diseases may be related to an individual's underlying susceptibility to develop autoimmune diseases. In this review, we will summarize the spectrum of coagulation disorders associated with thyroid diseases, discuss recent progress in the understanding of
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	0804-4643 1479-683X
DOI:	10.1530/eje.0.1360001