MicroRNA-mediated Regulation of LDL Receptor: Biological and Pharmacological Implications

• Published in: Current medicinal chemistry Vol. 31; no. 14; p. 1830
• Main Authors: Keshavarz, Reyhaneh, Reiner, Željko, Zengin, Gokhan, Eid, Ali H, Sahebkar, Amirhossein
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 01-01-2024
• Subjects: Animals; Atherosclerosis - drug therapy; Atherosclerosis - genetics; Atherosclerosis - metabolism; Cardiovascular Diseases - drug therapy; Cardiovascular Diseases - genetics; Cardiovascular Diseases - metabolism; Gene Expression Regulation; Humans; MicroRNAs - genetics; MicroRNAs - metabolism; Receptors, LDL - genetics; Receptors, LDL - metabolism; atherosclerosis; receptormediated endocytosis; MicroRNA; cellular cholesterol hemostasis; low-density lipoprotein receptor; low-density lipoprotein cholesterol
• ISSN: 1875-533X
• DOI: 10.2174/0929867330666230407091652

One of the main causes of atherosclerosis is a disruption in cellular cholesterol hemostasis. The low-density lipoprotein receptor (LDLR) is an important factor in maintaining cholesterol homeostasis by the receptor-mediated endocytosis of LDL particles. Defective hepatic LDLR activity and uptake of LDL particles lead to elevated blood levels of low-density lipoprotein cholesterol (LDL-C), which is associated with a higher risk of atherosclerotic cardiovascular disease. LDLR expression can be affected by microRNAs (miRNAs). Some miRNAs, like miR-148a, miR-185, miR-224, miR-520, miR-128-1, miR-27a/b, miR-130b, and miR-301 seem to be important post-transcriptional regulators of LDLR related genes. These findings indicate the critical role of miRNAs in regulating LDL metabolism. The aim of this review was to provide insight into the miRNAs involved in LDLR activity and their potential roles in the treatment of cardiovascular disease.